Journal article

The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls

RB Fogel, J Trinder, DP White, A Malhotra, J Raneri, K Schory, D Kleverlaan, RJ Pierce

Journal of Physiology | BLACKWELL PUBLISHING LTD | Published : 2005


Pharyngeal dilator muscles are important in the pathophysiology of obstructive sleep apnoea syndrome (OSA). We have previously shown that during wakefulness, the activity of both the genioglossus (GGEMG) and tensor palatini (TPEMG) is greater in patients with OSA compared with controls. Further, EMG activity decreases at sleep onset, and the decrement is greater in apnoea patients than in healthy controls. In addition, it is known that the prevalence of OSA is greater in middle-aged compared with younger men. Thus, we had two goals in this study. First we compared upper airway muscle activity between young and middle-aged healthy men compared with men with OSA. We also explored the mechanism..

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