Journal article

Functional analysis of granzyme M and its role in immunity to infection

LI Pao, N Sumaria, JM Kelly, S van Dommelen, E Cretney, ME Wallace, DA Anthony, AP Uldrich, DI Godfrey, JM Papadimitriou, A Mullbacher, MA Degli-Esposti, MJ Smyth

Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2005

Abstract

Cytotoxic lymphocytes express a large family of granule serine proteases, including one member, granzyme (Grz)M, with a unique protease activity, restricted expression, and distinct gene locus. Although a number of Grzs, including GrzM, have been shown to mediate target cell apoptosis in the presence of perforin, the biological activity of Grz has been restricted to control of a number of viral pathogens, including two natural mouse pathogens, ectromelia, and murine CMV (MCMV). In this article, we describe the first reported gene targeting of GrzM in mice. GrzM-deficient mice display normal NK cell/T cell development and homeostasis and intact NK cell-mediated cytotoxicity of tumor targets a..

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