Journal article

The role of A beta peptides in Alzheimer's disease

AK Tickler, JD Wade, F Separovic

Protein and Peptide Letters | BENTHAM SCIENCE PUBL LTD | Published : 2005

Abstract

The Abeta peptide has been identified as central to the onset and development of Alzheimer's disease (AD) and several hypotheses about toxicity involving Abeta peptides have been proposed including mechanisms of oxidative stress and disruption of calcium homeostasis. The biology, structure and physical properties of Abeta peptides are discussed, as well as existing therapeutics and future strategies for the treatment of AD.