Obstetric complications and transition to psychosis in an 'ultra' high risk sample

Abstract

Objective: An association between birth and pregnancy complications and the later development of schizophrenia has been described for decades and obstetric complications (OCs) have been proposed as a vulnerability marker for psychosis in line with the neurodevelopmental hypothesis of psychotic disorders. Previous studies of OCs have focused on established schizophrenia. In this study, the association between OCs and the development of psychotic disorder was studied in a group of 74 young people identified as being at very high risk for the first onset of psychosis. Method: The 'ultra' high risk (UHR) cohort was identified by the presence of subthreshold psychotic symptoms, or a combination o..