Journal article

Lateralized deficit of response inhibition in early-onset schizophrenia

MA Bellgrove, CD Chambers, A Vance, N Hall, M Karamitsios, JL Bradshaw

Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2006

Abstract

BACKGROUND: The ability to inhibit inappropriate or unwanted actions is a key element of executive control. The existence of executive function deficits in schizophrenia is consistent with frontal lobe theories of the disorder. Relatively few studies have examined response inhibition in schizophrenia, and none in adolescent patients with early-onset schizophrenia (EOS). METHODS: Twenty-one adolescents with the onset of clinically impairing psychosis before 19 years of age and 16 matched controls performed a stop-signal task to assess response inhibition. The patients with EOS were categorized as paranoid (n = 10) and undifferentiated subtypes (n = 11). The undifferentiated group had higher l..

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