Journal article

Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice

H Chen, R Vlahos, S Bozinovski, J Jones, GP Anderson, MJ Morris

Neuropsychopharmacology | NATURE PUBLISHING GROUP | Published : 2005


Although nicotinic receptors have been demonstrated in hypothalamic appetite-regulating areas and nicotine administration alters food intake and body weight in both animals and humans, the mechanisms underlying the effects of smoking on appetite circuits remain unclear. Conflicting effects of nicotine on the major orexigenic peptide, neuropeptide Y (NPY), have been observed in the brain, but the effects of smoking are unknown. Thus, we aimed to investigate how cigarette smoking affects body weight, food intake, plasma leptin concentration, hypothalamic NPY peptide, adipose mass and mRNA expression of uncoupling proteins (UCP), and tumor necrosis factor (TNF) alpha. Balb/C mice (8 weeks) were..

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