Journal article

(G)-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

E Kostenis, G Milligan, A Christopoulos, CF Sanchez-Ferrer, S Heringer-Walther, PM Sexton, F Gembardt, E Kellett, L Martini, P Vanderheyden, HP Schultheiss, T Walther

Circulation | LIPPINCOTT WILLIAMS & WILKINS | Published : 2005


BACKGROUND: We previously identified the G-protein-coupled receptor Mas, encoded by the Mas proto-oncogene, as an endogenous receptor for the heptapeptide angiotensin-(1-7); however, the receptor is also suggested to be involved in actions of angiotensin II. We therefore tested whether this could be mediated indirectly through an interaction with the angiotensin II type 1 receptor, AT1. METHODS AND RESULTS: In transfected mammalian cells, Mas was not activated by angiotensin II; however, AT1 receptor-mediated, angiotensin II-induced production of inositol phosphates and mobilization of intracellular Ca2+ was diminished by 50% after coexpression of Mas, despite a concomitant increase in angio..

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