Journal article

Distribution of tccP in clinical enterohemorrhagic and enteropathogenic Escherichia coli isolates

J Garmendia, ZH Ren, S Tennant, M Aparecida, M Viera, YW Chong, A Whale, K Azzopardi, S Dahan, MP Sircili, MR Franzolin, LR Trabulsi, A Phillips, TAT Gomes, JG Xu, R Robins-Browne, G Frankel

Journal of Clinical Microbiology | AMER SOC MICROBIOLOGY | Published : 2005


Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) are diarrheagenic pathogens that colonize the gut through the formation of attaching and effacing lesions, which depend on the translocation of effector proteins via a locus of enterocyte effacement-encoded type III secretion system. Recently, two effector proteins, EspJ and TccP, which are encoded by adjacent genes on prophage CP-933U in EHEC O157:H7, have been identified. TccP consists of a unique N-terminus region and several proline-rich domains. In this project we determined the distribution of tccP in O157:H7, in non-O157 EHEC, and in typical and atypical EPEC isolates. All the EHEC O157:H7 strains tested wer..

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