Journal article

Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use

SA Thomson, AB Jaramillo, M Shoobridge, KJ Dunstan, B Everett, C Ranasinghe, SJ Kent, K Gao, J Medveckzy, RA Ffrench, IA Ramshaw

VACCINE | ELSEVIER SCI LTD | Published : 2005


Induction of high levels of broadly reactive cytotoxic T lymphocytes (CTL) remains a promising approach for an effective HIV-1 vaccine. We have developed a novel genetic-based vaccine strategy that encodes consensus overlapping peptide sets from all HIV-1 proteins scrambled together. This synthetic scrambled antigen vaccine (SAVINE) strategy has significant advantages, e.g. capacity to encode more antigens safely and is very flexible compared to traditional isolate-based strategies. The SAVINE vaccine strategy is clearly immunogenic, being able to restimulate a range of human HIV-1 specific responses in vitro and induce HIV-1 specific immunity in vivo in mice. Interestingly, different in viv..

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University of Melbourne Researchers