Journal article

Connective tissue growth factor and cardiac fibrosis after myocardial infarction

RG Dean, LC Balding, R Candido, WC Burns, ZM Cao, SM Twigg, LM Burrell

Journal of Histochemistry and Cytochemistry | SAGE PUBLICATIONS LTD | Published : 2005


The temporal and spatial expression of transforming growth factor (TGF)-beta(1) and connective tissue growth factor (CTGF) was assessed in the left ventricle of a myocardial infarction (MI) model of injury with and without angiotensin-converting enzyme (ACE) inhibition. Coronary artery ligated rats were killed 1, 3, 7, 28, and 180 days after MI. TGF-beta(1), CTGF, and procollagen alpha1(I) mRNA were localized by in situ hybridization, and TGF-beta(1) and CTGF protein levels by immunohistochemistry. Collagen protein was measured using picrosirius red staining. In a separate group, rats were treated for 6 months with an ACE inhibitor. There were temporal and regional differences in the express..

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University of Melbourne Researchers