Low-molecular weight advanced glycation end products: Markers of tissue AGE accumulation and more?
MC Thomas, JM Forbes, R MacIsaac, G Jerums, ME Cooper, JW Baynes (ed.), VM Monnier (ed.), JM Ames (ed.), SR Thorpe (ed.)
Annals of The New York Academy of Sciences | NEW YORK ACAD SCIENCES | Published : 2005
Incomplete digestion of advanced glycation end product (AGE)-modified protein results in the formation of low-molecular weight degradation products incorporating AGE modifications (LMW-AGEs). In addition to being biomarkers of AGE modification, LMW-AGEs may have a high toxic potential, being free to interact with AGE receptors at distant sites via the circulation. Several free AGEs have been identified, including pentosidine, N(epsilon)-(carboxymethyl)lysine (CML), and free-imidazole AGEs. In addition, fluorescence (370 nm [excitation]/440 nm [emission]) in the LMW phase of serum correlates with tissue fluorescence, an established marker for AGE modification. In experimental diabetes, LMW fl..View full abstract