Renal hyperfiltration in type 2 diabetes: Effect of age-related decline in glomerular filtration rate

Abstract

Aims/hypothesis: We sought to characterise the effect of the age-related decline of GFR on hyperfiltration in type 2 diabetes and to identify clinical characteristics associated with hyperfiltration. Materials and methods: GFR was measured in 662 type 2 diabetic patients by plasma disappearance of 99 m-technetium-diethylene-triamine-penta-acetic acid. The prevalence of hyperfiltration was calculated using both an age-unadjusted GFR threshold of >130 ml min-1 1.73 m-2 and an age-adjusted threshold incorporating a decline of 1 ml min-1 year-1 after the age of 40. The hyperfiltering patients were compared with type 2 diabetic subjects who had a GFR between 90 and 130 ml min-1 1.73 m-2 and were ..