Journal article

Short-term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen

GK McConell, RS Lee-Young, ZP Chen, NK Stepto, NN Huynh, TJ Stephens, BJ Canny, BE Kemp

Journal of Physiology | WILEY-BLACKWELL | Published : 2005


We examined the effect of short-term exercise training on skeletal muscle AMP-activated protein kinase (AMPK) signalling and muscle metabolism during prolonged exercise in humans. Eight sedentary males completed 120 min of cycling at 66 +/- 1% , then exercise trained for 10 days, before repeating the exercise bout at the same absolute workload. Participants rested for 72 h before each trial while ingesting a high carbohydrate diet (HCHO). Exercise training significantly (P < 0.05) attenuated exercise-induced increases in skeletal muscle free AMP: ATP ratio and glucose disposal and increased fat oxidation. Exercise training abolished the 9-fold increase in AMPK alpha2 activity observed during..

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University of Melbourne Researchers