Journal article

Multi-envelope HIV-1 vaccine devoid of SIV components controls disease in macaques challenged with heterologous pathogenic SHIV

XY Zhan, LN Martin, KS Slobod, C Coleclough, TD Lockey, SA Brown, J Stambas, M Bonsignori, RE Sealy, JL Blanchard, JL Hurwitz

Vaccine | ELSEVIER SCI LTD | Published : 2005

Abstract

A central obstacle to the design of a global HIV-1 vaccine is virus diversity. Pathogen diversity is not unique to HIV-1, and has been successfully conquered in other fields by the creation of vaccine cocktails. Here we describe the testing of an HIV-1 envelope cocktail vaccine. Six macaques received the vaccine, delivered by successive immunizations with recombinant DNA, recombinant vaccinia virus and recombinant envelope proteins. Following vaccination, animals developed a diversity of anti-envelope antibody binding and neutralizing activities toward proteins and viruses that were not represented by sequence in the vaccine. T-cells were also elicited, as measured by gamma-interferon produc..

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University of Melbourne Researchers