Journal article
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
James E Galagan, Sarah E Calvo, Christina Cuomo, Li-Jun Ma, Jennifer R Wortman, Serafim Batzoglou, Su-In Lee, Meray Baştürkmen, Christina C Spevak, John Clutterbuck, Vladimir Kapitonov, Jerzy Jurka, Claudio Scazzocchio, Mark Farman, Jonathan Butler, Seth Purcell, Steve Harris, Gerhard H Braus, Oliver Draht, Silke Busch Show all
Nature | Springer Science and Business Media LLC | Published : 2005
DOI: 10.1038/nature04341
Abstract
The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake, miso and soy sauce. Our analysis of genome structure provided a quantitative evaluation of forces driving long-term eukaryotic genome evolution. It also led to an experimentally validated model of mating-type locus evolution, suggesting the potential for sexual reproduction in A. fumigatus and A. oryzae. Our analysis of sequence conservation revealed over 5,000 non-coding regio..
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