Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy

Abstract

Aim: To compare glycaemic control and symptomatic hypoglycaemia rates with glargine versus neutral protamine Hagedorn (NPH) in poorly controlled type 1 diabetes patients. Methods: Patients (n = 125) received preprandial insulin lispro and either glargine (n = 62) or NPH (n = 63) at bedtime for 30 weeks in a multicentre, randomized, single-blind (a blinded investigator made titration decisions) study. Basal insulin dosage was titrated to achieve fasting blood glucose (FBG) values <5.5 mmol/L. Results: Baseline characteristics were similar for the two groups (mean diabetes duration 17.5 ± 10.1 years) except mean glycated haemoglobin (HbA1c), which was lower in the glargine versus NPH group (9...