Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcγ receptor IIa-transgenic mice

Abstract

Objective. The major human Fc receptor, FcγRIIa, is the most widespread activating FcR. Our aim was to determine the role of FcyRIIa in a transgenic mouse model of immune complex-mediated autoimmunity and to characterize the development of spontaneous autoimmune disease. Methods. Arthritis was induced in normal and FcγRIIa-transgenic mice by immunization with type II collagen (CII) or by transfer of arthritogenic anti-CII antibodies. Also, mice that spontaneously developed autoimmune disease were assessed by clinical scoring of affected limbs, histology and serology, and measurement of autoantibody titers and cytokine production. Results. FcγRIIa-transgenic mice developed collagen-induced ar..