Journal article

Angiotensin II and norepinephrine release: interaction and effects on the heart

MP Schlaich, DM Kaye, E Lambert, J Hastings, DJ Campbell, G Lambert, MD Esler

Journal of Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2005

Abstract

BACKGROUND: Angiotensin (Ang) II may enhance the influence of the sympathetic nervous system at various levels by facilitating norepinephrine (NE) release. We investigated whether such an interaction is evident in the human heart and whether it has an impact on left ventricular (LV) structure. METHODS AND RESULTS: Ang I and Ang II concentrations were determined in arterial and coronary sinus (CS) plasma samples in a group of normotensive (n = 10) and hypertensive (n = 18) subjects. Total systemic and cardiac NE spillover was measured using isotope dilution methodology and LV structure by echocardiography. Arterial and CS concentrations of Ang I and Ang II were similar in both groups (Ang II ..

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