Journal article
The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation
FE Tynan, D Elhassen, AW Purcell, JM Burrows, NA Borg, JJ Miles, NA Williamson, KJ Green, J Tellam, L Kjer-Nielsen, J McCluskey, J Rossjohn, SR Burrows
JOURNAL OF EXPERIMENTAL MEDICINE | ROCKEFELLER UNIV PRESS | Published : 2005
DOI: 10.1084/jem.20050864
Abstract
Thousands of potentially antigenic peptides are encoded by an infecting pathogen; however, only a small proportion induce measurable CD8(+) T cell responses. To investigate the factors that control peptide immunogenicity, we have examined the cytotoxic T lymphocyte (CTL) response to a previously undefined epitope ((77)APQPAPENAY(86)) from the BZLF1 protein of Epstein-Barr virus (EBV). This peptide binds well to two human histocompatibility leukocyte antigen (HLA) allotypes, HLA-B*3501 and HLA-B*3508, which differ by a single amino acid at position 156 ((156)Leucine vs. (156)Arginine, respectively). Surprisingly, only individuals expressing HLA-B*3508 show evidence of a CTL response to the (7..
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