Journal article

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

FE Tynan, SR Burrows, AM Buckle, CS Clements, NA Borg, JJ Miles, T Beddoe, JC Whisstock, MC Wilce, SL Silins, JM Burrows, L Kjer-Nielsen, L Kostenko, AW Purcell, J McCluskey, J Rossjohn

NATURE IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2005

Abstract

Unusually long major histocompatibility complex (MHC) class I-restricted epitopes are important in immunity, but their 'bulged' conformation represents a potential obstacle to alphabeta T cell receptor (TCR)-MHC class I docking. To elucidate how such recognition is achieved while still preserving MHC restriction, we have determined here the structure of a TCR in complex with HLA-B(*)3508 presenting a peptide 13 amino acids in length. This complex was atypical of TCR-peptide-MHC class I interactions, being dominated at the interface by peptide-mediated interactions. The TCR assumed two distinct orientations, swiveling on top of the centrally bulged, rigid peptide such that only limited contac..

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