Journal article
PI 3-kinase p110β: A new target for antithrombotic therapy
SP Jackson, SM Schoenwaelder, I Goncalves, WS Nesbitt, CL Yap, CE Wright, V Kenche, KE Anderson, SM Dopheide, Y Yuan, SA Sturgeon, H Prabaharan, PE Thompson, GD Smith, PR Shepherd, N Daniele, S Kulkarni, B Abbott, D Saylik, C Jones Show all
Nature Medicine | NATURE PUBLISHING GROUP | Published : 2005
DOI: 10.1038/nm1232
Abstract
Platelet activation at sites of vascular injury is essential for the arrest of bleeding; however, excessive platelet accumulation at regions of atherosclerotic plaque rupture can result in the development of arterial thrombi, precipitating diseases such as acute myocardial infarction and ischemic stroke. Rheological disturbances (high shear stress) have an important role in promoting arterial thrombosis by enhancing the adhesive and signaling function of platelet integrin αIIbβ3 (GPIIb-IIIa). In this study we have defined a key role for the Type Ia phosphoinositide 3-kinase (PI3K) p110β isoform in regulating the formation and stability of integrin αIIbβ3 adhesion bonds, necessary for shear a..
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