Journal article

Prostaglandin E and F receptor expression and myometrial sensitivity at labor onset in the sheep

HK Palliser, JJ Hirst, GT Ooi, GE Rice, NL Dellios, RM Escalona, HC Parkington, IR Young

Biology of Reproduction | SOC STUDY REPRODUCTION | Published : 2005

Abstract

Prostaglandins (PGs) play a pivotal role in the initiation and progression of term and preterm labor. Uterine activity is stimulated primarily by PGE(2) and PGF(2alpha) acting on prostaglandin E (EP) and prostaglandin F (FP) receptors, respectively. Activation of FP receptors strongly stimulates the myometrium, whereas stimulation of EP receptors may lead to contraction or relaxation, depending on the EP subtype (EP1-4) expression. Thus, the relative expression of FP and EP1-4 may determine the responsiveness to PGE(2) and PGF(2alpha). The aims of this study were to characterize the expression of EP1-4 and FP in intrauterine tissues and placentome, together with myometrial responsiveness to ..

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