Journal article

Activation of thymic regeneration in mice and humans following androgen blockade

JS Sutherland, GL Goldberg, MV Hammett, AP Uldrich, SP Berzins, TS Heng, BR Blazar, JL Millar, MA Malin, AP Chidgey, RL Boyd

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2005

Abstract

The thymus undergoes age-related atrophy, coincident with increased circulating sex steroids from puberty. The impact of thymic atrophy is most profound in clinical conditions that cause a severe loss in peripheral T cells with the ability to regenerate adequate numbers of naive CD4+ T cells indirectly correlating with patient age. The present study demonstrates that androgen ablation results in the complete regeneration of the aged male mouse thymus, restoration of peripheral T cell phenotype and function and enhanced thymus regeneration following bone marrow transplantation. Importantly, this technique is also applicable to humans, with analysis of elderly males undergoing sex steroid abla..

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University of Melbourne Researchers