The haemodynamic and metabolic effects of epinephrine in experimental hyperdynamic septic shock

Abstract

OBJECTIVE: To study the effect of epinephrine (EPI) infusion on vital organ blood flow and metabolic variables during sepsis. DESIGN AND SETTING: Randomised placebo-controlled animal trial in an animal laboratory. ANIMALS: Seven merino cross-ewes. INTERVENTIONS: Chronic implantation of flow probes (aorta, renal, mesenteric and coronary artery and sagittal sinus). Induction of sepsis by intravenous injection of E. coli. Random allocation of sheep to EPI (0.4 microg kg(-1) min(-1)) or vehicle for 6 h. MEASUREMENTS AND RESULTS: E. coli induced hypotension and hyperlactataemia and increased cardiac output, renal, mesenteric and coronary blood flows. Compared to vehicle, EPI restored mean arteria..