Journal article

Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat

HB Stolp, KM Dziegielewska, CJ Ek, AM Potter, NR Saunders

European Journal of Neuroscience | WILEY | Published : 2005

Abstract

Epidemiological evidence in human fetuses links inflammation during development with white matter damage. Breakdown of the blood-brain barrier has been proposed as a possible mechanism. This was investigated in the present study by inducing a prolonged inflammatory response in newborn rats, with intraperitoneal injections of lipopolysaccharide (LPS; 0.2 mg/kg) given at postnatal (P) day 0, P2, P4, P6 and P8. An acute phase response was present over the whole period of injections. Changes in blood-brain barrier permeability were determined for small (sucrose and inulin) and large (protein) molecules. During and immediately after the inflammatory response, plasma proteins were detected in the ..

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