Journal article

Plasma acid-base changes in chronic renal failure: A Stewart analysis

DA Story, A Tosolini, R Bellomo, M Leblanc, L Bragantini, C Ronco

International Journal of Artificial Organs | SAGE PUBLICATIONS LTD | Published : 2005


The bicarbonate centered approach to acid-base physiology involves complex explanations for the metabolic acidosis associated with chronic renal failure. We used the alternate Stewart approach to acid-base physiology to quantify the acid-base chemistry of patients with chronic renal failure. We examined the plasma and urine chemistry of 19 patients with chronic renal failure who were predialysis and 20 healthy volunteers. We compared the plasma strong-ion-difference due to sodium,potassium,and chloride ions as well as the weak acids albumin and phosphate. We used a simplified Fencl-Stewart approach to quantify the effects of sodium-chloride, albumin, and unmeasured ions on base-excess. The c..

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