The vascular endothelium in diabetes: a practical target for drug treatment?
KL Andrews, M Pannirselvam, TJ Anderson, AJ Jenkins, CR Triggle, MA Hill
EXPERT OPINION ON THERAPEUTIC TARGETS | TAYLOR & FRANCIS LTD | Published : 2005
Vascular disease remains a major cause of morbidity and mortality in diabetes mellitus, in spite of recent improvements in outcome, some of which may be modulated by improved endothelial function. Therapeutic strategies aimed directly at preventing, or minimising the extent of, these sequelae are required as an adjunct to treatments directed at normalising the metabolic milieu. The microvasculature, and the endothelium in particular, are early contributors to vascular dysfunction, thus raising the question as to how best to specifically target the endothelium. However, the expansive nature of the microvasculature, the varying demands that tissues have in terms of blood flow, and the heteroge..View full abstract