Journal article

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutaselike structures and inhibition of neurotoxicity

AK Tickler, DG Smith, GD Ciccotosto, DJ Tew, CC Curtain, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, JD Wade, KJ Barnham

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2005

DOI: 10.1074/jbc.M414178200

University of Melbourne Researchers

Joe Ciccotosto Author Pharmacology and Therapeutics

Kevin Barnham Author Florey Department of Neuroscience and Mental Health

Ashley Bush Author Florey Department of Neuroscience and Mental Health

Colin Masters Author Florey Department of Neuroscience and Mental Health

Roberto Cappai Author Pharmacology and Therapeutics

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Keywords

Circular Dichroism

Alzheimer Disease

Electron Spin Resonance Spectroscopy

Science & Technology

Life Sciences & Biomedicine

Protein Structures

Free Radical Scavengers

Transgenic Mice

Molecular Structure

Superoxide Dismutase

Models, Molecular

Peptide Fragments

Biochemistry & Molecular Biology

Protein Structure, Secondary

Amyloid Beta-Peptides

Oxidation-Reduction