Journal article

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutaselike structures and inhibition of neurotoxicity

AK Tickler, DG Smith, GD Ciccotosto, DJ Tew, CC Curtain, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, JD Wade, KJ Barnham

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2005

DOI: 10.1074/jbc.M414178200

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Keywords

Amyloid Beta-Peptides
Imidazoles
Membranes
Protein Structures
Superoxide Dismutase
Free Radical Scavengers
Transgenic Mice
Zinc
Circular Dichroism
Humans
Female
Histidine
Science & Technology
Molecular Structure
Neurotoxins
Models, Molecular
Alzheimer Disease
Electron Spin Resonance Spectroscopy
Methylation
Metal-Ions
Copper
Binding Sites
A-Beta
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Toxicity
Peptide Fragments
Copper-Binding
Protein Structure, Secondary
Animals
Oxidation-Reduction
Complexes