Journal article

Site of primary tumor has a prognostic role in operable breast cancer: The International Breast Cancer Study Group experience

M Colleoni, D Zahrieh, RD Gelber, SB Holmberg, JE Mattsson, CM Rudenstam, J Lindtner, D Erzen, R Snyder, J Collins, MF Fey, B Thurlimann, D Crivellari, E Murray, C Mendiola, O Pagani, M Castiglione-Gertsch, AS Coates, K Price, A Goldhirsch

JOURNAL OF CLINICAL ONCOLOGY | AMER SOC CLINICAL ONCOLOGY | Published : 2005

Abstract

PURPOSE: Cancer presenting at the medial site of the breast may have a worse prognosis compared with tumors located in external quadrants. For medial tumors, axillary lymph node staging may not accurately reflect the metastatic potential of the disease. PATIENTS AND METHODS: Eight-thousand four-hundred twenty-two patients randomly assigned to International Breast Cancer Study Group clinical trials between 1978 and 1999 were classified as medial site (1,622; 19%) or lateral, central, and other sites (6,800; 81%). Median follow-up was 11 years. RESULTS: A statistically significant difference was observed for patients with medial tumors versus those with nonmedial tumors in disease-free surviva..

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