Journal article

Early processing deficits in object working memory in first-episode schizophreniform psychosis and established schizophrenia

B Mathes, SJ Wood, TM Proffitt, GW Stuart, JAM Buchanan, D Velakoulis, WJ Brewer, PD McGorry, C Pantelis

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2005

Abstract

BACKGROUND: While there are many studies showing working-memory deficits in schizophrenia there are only a few that disentangle impairments for working-memory subprocesses such as perceptual, attentional, mnemonic and executive function. METHOD: In this study of delay-dependent memory, 55 patients with schizophreniform psychosis, 50 with established schizophrenia and 56 healthy controls were investigated. Using the delayed matching-to-sample task from the Cambridge Neuropsychological Test Automated Battery (CANTAB), performance deficits were found in both patient groups after controlling for age and pre-morbid IQ. RESULTS: Even after controlling for simultaneous matching-to-sample ability (i..

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