Cortical release signs in psychiatry

Abstract

Objective: To review the role of cortical release signs (CRS) in neuropsychiatry. Method: A thorough literature review was conducted using Medline and Psychlit databases, and other relevant references available to the authors. Results: A number of neurological abnormalities are reported at elevated rates in neuropsychiatric conditions. CRS are a group of primitive reflexes that are present in the neonate but become inhibited as the infant central nervous system (CNS) develops, only to later re-emerge in the context of CNS disease. The clinical elicitation and interpretation of each CRS is described with reference to its neurobiology. The prevalence of CRS in schizophrenia, affective disorder..