Journal article

Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the AE sop first-onset psychosis study

CM Pariante, P Dazzan, A Danese, KD Morgan, F Brudaglio, C Morgan, P Fearon, K Orr, G Hutchinson, C Pantelis, D Velakoulis, PB Jones, J Leff, RM Murray



Subjects at their first psychotic episode show an enlarged volume of the pituitary gland, but whether this is due to hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, or to stimulation of the prolactin-secreting cells by antipsychotic treatment, is unclear. We measured pituitary volume, using 1.5-mm, coronal, 1.5 T, high-resolution MRI images, in 78 patients at the first psychotic episode and 78 age- and gender-matched healthy controls. In all, 18 patients were antipsychotic-free (12 of these were antipsychotic-naïve), 26 were receiving atypical antipsychotics, and 33 were receiving typical antipsychotics. As hypothesized, patients had a larger pituitary volume than controls (+22%, p<..

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