Journal article

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain

I Voskoboinik, MC Thia, J Fletcher, A Ciccone, K Browne, MJ Smyth, JA Trapani

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2005

DOI: 10.1074/jbc.M413303200

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Keywords

Mutations
Pore Forming Cytotoxic Proteins
Transfection
Gene
Perforin
Humans
Sheep
Familial Hemophagocytic Lymphohistiocytosis
Dose-Response Relationship, Drug
Structure-Activity Relationship
Mutation
Calcium
Dna, Complementary
Insects
Science & Technology
Lymphocytes
Protein Structure, Tertiary
Forming Protein Perforin
Animals
Lipid Metabolism
Complement C9
Membrane Glycoproteins
Biochemistry & Molecular Biology
Life Sciences & Biomedicine
Models, Molecular
T-Cells
Cytotoxicity
Time Factors
9th Component
Crystal-Structure
Aspartic Acid
Cell Membrane
Protein Conformation
Erythrocytes
Cell Line, Tumor
Rats
Natural-Killer-Cells
Hydrogen-Ion Concentration
Cell Line
Recombinant Proteins
Ligands
Protein Binding
Amino Acid Motifs
Jurkat Cells
Insecta