The gradient of retinal functional changes during acute intraocular pressure elevation

Abstract

PURPOSE. To characterize retinal function during a period of acutely elevated intraocular pressure (IOP) across a wide range of IOPs, including those typically observed in animals with experimental glaucoma. METHODS. Unilateral elevation of IOP was achieved manometrically in adult Brown Norway rats (nine experimental groups; n = 4-7 in each; 10-100 mm Hg and sham control). Full-field ERGs were recorded simultaneously from treated and control eyes, beginning 75 minutes after IOP elevation. Scotopic ERG stimuli were brief white flashes (-6.1 to 2.7 log cd-s/m2). Photopic ERGs were recorded (1.2-2.7 log cd-s/m2) after 15 minutes of light adaptation (150 cd/m2). Relative amplitude (treated/contr..