Cutaneous manifestations of systemic disease

Abstract

Background: While most patients who present with a rash have no associated systemic illness, many systemic illnesses have skin manifestations at some stage. Objective: This article uses case vignettes to illustrate a problem oriented approach to five commonly presented skin conditions that have common and varied systemic associations. A logical sequence of management for each case is provided. Discussion: Often the skin manifestations of systemic disease are vague and nonspecific such as the toxic erythema that might follow a viral infection or a drug eruption. Sometimes it is the systemic manifestations that are vague and nonspecific, while the skin manifestations are highly specific and de..