Journal article

Expression of the carrier protein apolipoprotein D in the mouse inner ear

MS Hildebrand, MG de Silva, T Klockars, CA Solares, K Hirose, JD Smith, SC Patel, HHM Dahl

HEARING RESEARCH | ELSEVIER SCIENCE BV | Published : 2005

Abstract

The cochlear portion of the inner ear converts movements produced by sound waves into electrical impulses. Transcripts enriched in the cochlea are likely to have an important role in hearing. In this paper, we report that microarray analyses of the Soares NMIE inner ear library revealed cochlear enriched expression of apolipoprotein D (apoD), a glycoprotein and member of the lipocalin family that transport small hydrophobic ligands. The cochlear enriched expression of Apod was validated by quantitative real time PCR analysis. To investigate the function of apoD in the inner ear the transcript and protein were localised in the cochlea. Apod messenger RNA (mRNA) expression was localised to the..

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