Journal article

Attempted randomized controlled trial of pamidronate versus calcium and calcitriol supplements for management of steroid-induced osteoporosis in children and adolescents

JJ Brown, MR Zacharin

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | WILEY | Published : 2005

Abstract

OBJECTIVES: To describe an attempted interventional trial for glucocorticoid-induced osteoporosis in children and adolescents and to discuss the reasons for trial failure to inform future interventional studies in this important group of patients. METHODS: Prospective randomized controlled trial comparing the effect of bisphosphonate therapy with calcium and vitamin D supplementation on bone mineral accrual is described. For non-trial patients, retrospective analysis of the effect of calcium and vitamin D supplementation combined with bisphosphonate treatment on bone mineral accrual. RESULTS: Only 12 patients were enrolled in the trial over 4 years. Bisphosphonate recipients (n = 5) had a me..

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