Journal article

Assessing regional hypoxia in human renal tumours using 18F-fluoromisonidazole positron emission tomography

N Lawrentschuk, AMT Poon, SS Foo, LGJ Putra, C Murone, ID Davis, DM Bolton, AM Scott

BJU INTERNATIONAL | WILEY | Published : 2005

Abstract

OBJECTIVE: To assess renal tumours for hypoxic regions using 18F-fluoromisonidazole (18F-FMISO) positron emission tomography (PET), a recognized noninvasive method for detecting hypoxia in tumours, as renal cell carcinoma (RCC) can be potentially cured with nephrectomy but recurrence develops in most patients, who then respond poorly to treatments such as chemotherapy, and hypoxia is known to confer resistance to radiotherapy and chemotherapy in many solid tumours. PATIENTS AND METHODS: In all, 17 patients had 18F-FMISO PET scans before nephrectomy for presumed RCC. Specimens were examined histologically, and immunohistochemistry was used to compare the microvessel density (MVD) as an indica..

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