Journal article
Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi
AP Alker, V Mwapasa, A Purfield, SJ Rogerson, ME Molyneux, DD Kamwendo, E Tadesse, E Chaluluka, SR Meshnick
Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2005
Abstract
We conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Grants
Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development