Journal article

Coagulation activation and organ dysfunction following cardiac surgery

B Dixon, J Santamaria, D Campbell

CHEST | AMER COLL CHEST PHYSICIANS | Published : 2005

Abstract

STUDY OBJECTIVES: Cardiac surgery with cardiopulmonary bypass (CPB) is associated with major inflammatory triggers that cause marked activation of the microcirculation. This inflammatory response is associated with significant organ dysfunction. How this response causes organ dysfunction is not well understood; consequently, few interventions exist to prevent or treat it. In other acute inflammatory conditions, such as sepsis, increased coagulation activation in the microcirculation may be a cause of organ injury. We documented the association between coagulation activation and organ dysfunction to investigate whether coagulation activation also plays a role in organ injury following cardiac..

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