Journal article

Modulation of osteopontin in proteinuria-induced renal interstitial fibrosis

AB Kramer, SD Ricardo, DJ Kelly, F Waanders, H van Goor, G Navis

JOURNAL OF PATHOLOGY | JOHN WILEY & SONS LTD | Published : 2005

Abstract

Proteinuria is associated with macrophage-dependent interstitial fibrosis (IF). Osteopontin (OPN), a macrophage chemoattractant, may be involved in the transition of proteinuria to IF but protective properties have also been reported. To elucidate whether OPN may be involved in the proteinuria-induced cascade of tubulointerstitial damage, renal expression of OPN was studied during the development of proteinuria-induced renal damage and during anti-proteinuric intervention with ACE inhibition (ACEi). First, the temporal relationships between proteinuria, interstitial OPN induction, and IF in adriamycin nephrosis (AN), a model of chronic proteinuria-induced renal damage, were studied. Second, ..

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