G-Protein-coupled receptor-protein interactions: basis for new concepts on receptor structure and function.
Nanda Tilakaratne, Patrick M Sexton
Clinical and Experimental Pharmacology and Physiology | Wiley | Published : 2005
1. G-Protein-coupled receptors (GPCRs) constitute a large family of cell surface proteins. Their primary function is to transmit extracellular stimuli to intracellular signals. It is estimated that the human genome contains more than 1000 genes that code for proteins of the GPCR structure. These receptors also comprise the most important class of therapeutic drug targets. 2. The mechanism of GPCR signalling was initially envisioned as involving coupling to the heterotrimeric G-proteins only. However, recent developments in the field suggest that such a simplistic model cannot be sustained any longer. The emerging view is that a wide range of accessory proteins are involved in the regulation ..View full abstract