Journal article

8-OH-DPAT-induced effects on prepulse inhibition: Pre- vs. post-synaptic 5-HT1A receptor activation

A Gogos, S Kusljic, M van den Buuse

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2005

Abstract

Prepulse inhibition (PPI) is a measure of sensorimotor gating that is deficient in schizophrenia. In rats, administration of the serotonin-1A (5-HT1A) receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), causes a disruption of PPI. It is unclear whether this effect is due to the activation of pre- or post-synaptic 5-HT1A receptors, however pre-synaptic receptors located in the dorsal raphe nucleus (DRN) may play a role. Our previous research showed that castrated rats have a reduced sensitivity to 8-OH-DPAT-induced disruptions of PPI. Therefore, in , male Sprague-Dawley rats were sham-operated or castrated and micro-injected with 8-OH-DPAT directly into the DRN. In , male ra..

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