Journal article

Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss

Hui Chen, Michelle J Hansen, Jessica E Jones, Ross Vlahos, Steve Bozinovski, Gary P Anderson, Margaret J Morris

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | AMER THORACIC SOC | Published : 2006

Abstract

RATIONALE: Despite irrefutable epidemiologic evidence, cigarette smoking remains the major preventable cause of lung disease morbidity worldwide. The appetite-suppressing effect of tobacco is a major behavioral determinant of smoking, but the underlying molecular and neuronal mechanisms are not understood. Neuropeptide Y (NPY) is an orexigenic neuropeptide, whose activity in the hypothalamic paraventricular nucleus governs appetite. OBJECTIVES: To compare the effects of smoke exposure and equivalent food restriction on body weight, organ mass, cytokines, and brain NPY in Balb/c mice. METHODS: A pair-feeding study design compared smoke exposure (4 wk; 1 cigarette, 3 x /d, 5 d/wk) to equivalen..

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