Journal article

The extent of resection of FDG-PET hypometabolism relates to outcome of temporal lobectomy

Anita B Vinton, Ross Carne, Rodney J Hicks, Patricia M Desmond, Christine Kilpatrick, Andrew H Kaye, Terence J O'Brien

BRAIN | OXFORD UNIV PRESS | Published : 2007

Abstract

A significant minority of patients undergoing surgery for medically refractory non-lesional temporal lobe epilepsy (TLE) continue to have seizures, but the reasons for this are uncertain. Fluorodeoxyglucose (FDG) PET shows hypometabolism in a majority of patients with non-lesional TLE, even in the absence of hippocampal atrophy. We examined whether the extent of resection of the area of FDG-PET hypometabolism influenced outcome following surgery for non-lesional TLE. Twenty-six patients who underwent temporal lobectomy for medically refractory TLE with at least 12 months follow-up were studied. The preoperative FDG-PET was compared with 20 non-epileptic controls using SPM99 to identify regio..

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