Journal article

The synthesis and biological evaluation of lactose-based sialylmimetics as inhibitors of rotaviral infection

A Liakatos, MJ Kiefel, F Fleming, B Coulson, M von Itzstein

BIOORGANIC & MEDICINAL CHEMISTRY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2006

Abstract

Rotaviruses are the most significant cause of gastroenteritis in young children and are responsible for over 600,000 infant deaths annually. The rotaviral haemagglutinin protein (VP8*) of some strains has been implicated in early recognition and binding events of host cell-surface sialoglycoconjugates, and is therefore an attractive target for potential therapeutic intervention. Since N-acetylneuraminic acid alpha(2,3)-linked to galactose is believed to be the minimum binding epitope of rotavirus to host cells, we report here our development of an efficient and flexible synthetic route to a range of lactose-based sialylmimetics of alpha(2,3)-linked thiosialosides. These compounds were biolog..

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University of Melbourne Researchers