Journal article

Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam

Nguyen L Toan, Le H Song, Peter G Kremsner, Dinh N Duy, Vu Q Binh, Bernd Koeberlein, Stefan Kaiser, Reinhard Kandolf, Joseph Torresi, C-Thomas Bock

HEPATOLOGY | WILEY | Published : 2006


Eight genotypes (A-H) of hepatitis B virus (HBV) have been identified. However, the impact of different genotypes on the clinical course of hepatitis B infection remains controversial. We investigated the frequency and clinical outcome of HBV genotypes and genotype mixtures in HBV-infected patients from Vietnam, Europe, and Africa. In addition, we analyzed the effects of genotype mixtures on alterations in in vitro viral replication. In Asian patients, seven genotypes (A-G) were detected, with A, C, and D predominating. In European and African patients, only genotypes A, C, D, and G were identified. Genotype mixtures were more frequently encountered in African than in Asian (P = .01) and Eur..

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University of Melbourne Researchers