Establishment and recall of CD8 T-cell memory in a model of localized transient infection

Abstract

The influenza A virus model of localized, transient respiratory infection provides a well-defined experimental system for dissecting the induction and maintenance of CD8+ T-cell memory. This review focuses on quantitative and qualitative aspects of the prominent DbNP 366- and DbPA224-specific CD8+ T-cell responses in virus-infected B6 mice. The different virus-specific effector and memory sets are compared by phenotypic [CD62L, interleukin-7 receptor-α (IL-7Rα), and IL-15Rβ expression] and functional [interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and IL-2 production] analyses. Most clonotypes [defined by T-cell receptor (TCR) CDR3β sequence] generated during the acute phase of infec..