Journal article
Characterization of Fluoromisonidazole Binding in Stroke
Neil J Spratt, Uwe Ackerman, Henri J Tochon-Danguy, Geoffrey A Donnan, David W Howells
Stroke | Ovid Technologies (Wolters Kluwer Health) | Published : 2006
Abstract
Background and Purpose— [ 18 F]fluoromisonidazole (FMISO) positron emission tomography has been used to image hypoxia early after human stroke. To further study the role of hypoxia in stroke and the binding characteristics of FMISO, we aimed to develop [ 3 H]FMISO autoradiography in an animal stroke model. We hypothesized that [ 3 H]FMISO binding is prolonged, allowing correlation with 24-hour histology, and that there is no FMISO binding after effective reperfusion. Methods— Temporary middle cerebral artery (MCA) occlusion..
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