The population burden of fractures originates in women with osteopenia, not osteoporosis

Abstract

IntroductionOsteoporosis is associated with increased risk for fracture. However, most postmenopausal women have bone mineral density (BMD) within the normal or osteopenic range. The aim of this study was to determine the proportion of the population burden of fragility fractures arising from women at modest risk for fracture.MethodsWe measured baseline BMD in a population-based random sample of 616 postmenopausal women aged 60–94 years and followed these individuals for a median of 5.6 years (IQR 3.9–6.5) to determine the incidence of fractures according to age, BMD and the presence of a prior fracture.ResultsBased on WHO criteria, 37.6% of the women had normal total hip BMD, 48.0% had oste..